Treatment Resistant Minimal Change Disease

Similar to FSGS, treatment-resistant minimal change disease (TR-MCD), is a rare kidney disorder characterized by podocyte injury and is an important cause of nephrotic syndrome in children as well as adults. Clinical hallmarks of MCD include rapid onset of edema and weight gain. While MCD may be managed with corticosteroids, a subset of patients fail to respond and are considered treatment-resistant. There are currently no FDA approved treatments available for patients with TR-MCD.

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